|
KMID : 1141520210360061151
|
|
Endocrinology and Metabolism
2021 Volume.36 No. 6 p.1151 ~ p.1160
|
|
|
Serotonergic Regulation of Hepatic Energy Metabolism
|
|
Park Ji-Won
Jeong Woo-Ju
Yun Cha-Hyeon
Kim Ha-Il
Oh Chang-Myung
|
|
|
Abstract
|
|
|
|
The liver is a vital organ that regulates systemic energy metabolism and many physiological functions. Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease and end-stage liver failure. NAFLD is primarily caused by metabolic disruption of lipid and glucose homeostasis. Serotonin (5-hydroxytryptamine [5-HT]) is a biogenic amine with several functions in both the central and peripheral systems. 5-HT functions as a neurotransmitter in the brain and a hormone in peripheral tissues to regulate systemic energy homeostasis. Several recent studies have proposed various roles of 5-HT in hepatic metabolism and inflammation using tissue-specific knockout mice and 5-HT-receptor agonists/antagonists. This review compiles the most recent research on the relationship between 5-HT and hepatic metabolism, and the role of 5-HT signaling as a potential therapeutic target in NAFLD.
|
|
|
KEYWORD
|
|
|
Serotonin, Liver, Non-alcoholic fatty liver disease
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|